自适应SA-PSO优化的威布尔混合分布参数估计方法及应用

针对采用传统参数估计方法得到的模型拟合误差较大的问题，建立多重威布尔混合分布参数估计的非线性最小二乘模型，并提出基于模拟退火（SA）思想的自适应粒子群（PSO）算法进行求解。在PSO算法优化过程中，采用自适应方法调整惯性权重和加速因子，加快其收敛速度；引入模拟退火机制，根据Metropolis准则确定最优粒子的取舍，改善其全局搜索能力。将该方法应用到某型柴油机喷油器失效分布的参数估计中，并与图解法、基于Levenberg-Marquardt的非线性最小二乘法、标准PSO算法、自适应PSO算法求解的结果进行比较，分析所提方法的优化性能及精度。结果表明，该方法能够有效提高多重威布尔混合分布模型参数估计的精度和效率。     

扭转参数对铜合金接触线扭转圈数影响研究

铜合金接触线在安装、使用等过程中不可避免存在扭转现象,不同的扭转参数对铜合金接触线的最大扭转圈数存在一定影响。本文通过扭转试验研究了扭转速度、张力以及扭转方向等参数对CTMH150接触线扭转圈数的影响,并分析了扭矩与扭转圈数的关系。研究发现,铜合金接触线的扭转圈数随着扭转速度、张力的增大先降低再增加,均存在一个转换点；双向扭转过程中的扭矩圈数大于单向扭转。此外,接触线的扭矩与扭转圈数成线性相关性。     

Evaluation of the pore morphology formation of the Freeze Foaming process by in situ computed tomography

The so-called Freeze Foaming method aims at manufacturing ceramic cellular scaffolds for diverse applications. One application is dedicated to potential bone replacement material featuring open, micro and interconnected porosity. However, the main challenges of this foaming method is to achieve a homogeneous pore morphology. In a current project, the authors throw light on the bubble/pore and strut formation of this process by in situ computed tomography. This allows for evaluating varying process parameter’s effects on the growth of the ceramic foam during the foaming process. As first result and basis for CT analysis, a stable and reproducible model suspension was developed which resulted in reproducible foam structures. In dependence of selected process parameters like pressure reduction rate or air content in the ceramic suspension resulting Freeze Foams became adjustable with regard to their pore morphology. Pore size and distribution data as well as the porosity were characterized and evaluated accordingly.     

透明红外硫系薄膜非均匀性检测及影响因素

薄膜非均匀性的无损检测对于制备大面积高质量的红外透明薄膜尤为重要。针对红外薄膜光学均匀性难以获取的困难,提出了一种同时获得单层透明红外薄膜厚度和折射率均匀性的无损检测方法。实验上,通过磁控溅射法在二氧化硅衬底上制备了厚度约1.4μm红外透明Ge-Sb-Se硫系薄膜,然后在该薄膜上标定出36个80μm×80μm区域,利用显微傅里叶红外光谱仪测得该36个区域的透射谱,通过分段滤波的方法滤除背景噪声,运用改进的Swanepoel方法计算得到了薄膜每一个区域的厚度和折射率,进而精确获得该薄膜的厚度和折射率均匀性,结果表明精度优于0.5%。     

气候环境实验室地面结冰云雾模拟控制系统设计

飞机结冰会引起飞机气动特性、动力系统性能改变,甚至造成飞行事故。地面结冰云雾模拟设施作为一种模拟飞机飞行结冰条件的重要设备,常用于飞机防除冰系统功能验证。针对气候环境实验室结冰云雾试验条件需要,在对地面结冰云雾模拟系统进行研究的基础上,对适用于气候环境实验室的结冰云雾模拟系统进行了设计。对系统关键设计技术、系统功能及组成进行了分析,并对控制系统方案进行了详细阐述。试验表明,控制系统人机界面友好,运行可靠,能够满足液态水含量、雾滴直径参数的精确调节,产生符合试验所需的结冰环境。     

Molecular Features and Clinical Management of Hereditary Gynecological Cancers

Hereditary gynecological cancers are caused by several inherited genes. Tumors that arise in the female reproductive system, such as ovaries and the uterus, overlap with hereditary cancers. Several hereditary cancer-related genes are important because they might lead to therapeutic targets. Treatment of hereditary cancers should be updated in line with the advent of various new methods of evaluation. Next-generation sequencing has led to rapid, economical genetic analyses that have prompted a concomitant and significant paradigm shift with respect to hereditary cancers. Molecular tumor profiling is an epochal method for determining therapeutic targets. Clinical treatment strategies are now being designed based on biomarkers based on tumor profiling. Furthermore, the National Comprehensive Cancer Network (NCCN) guidelines significantly changed the genetic testing process in 2020 to initially consider multi-gene panel (MGP) evaluation. Here, we reviewed the molecular features and clinical management of hereditary gynecological malignancies, such as hereditary breast and ovarian cancer (HBOC), and Lynch, Li–Fraumeni, Cowden, and Peutz–Jeghers syndromes. We also reviewed cancer-susceptible genes revealed by MGP tests.     

内插螺旋立式上行管流场及传热性能的实验研究

通过粒子图像测速流场实验与传热实验相结合，研究了内插螺旋立式上行管的螺旋节距、丝径、中径比等结构参数在不同Re下对流场、阻力及传热性能的影响。结果表明，内插螺旋能够有效扰动和混合管内流体，使管内形成多个纵向旋涡的流体结构、增大管壁附近液体涡量，有利于强化传热。当Re相同时，管内平均流速v、Nu和综合换热性能PEC均随丝径增大而增大，随中径比减小而增大；随节距增大，3种参数均出现增大的趋势，节距大于20 mm后开始减小。管内流体的阻力f随丝径和节距增大而减小，随中径比增大而增大。综合比较，在较低Re时，节距p=20 mm、丝径e=1.6 mm、中径比D/d=0.75时综合传热效果最好。     

基于液压活塞式惯容器的车辆悬架性能研究

阐述了液压活塞式惯容器的基本结构、工作原理与承载力大的特点，建立了考虑摩擦力、寄生阻尼力和油液弹性效应的惯容器非线性力学模型。在数控液压伺服激振台上对液压活塞式惯容器进行了力学性能试验，基于试验结果，利用Matlab参数辨识工具箱对非线性力学模型中的参数进行辨识。在此基础上建立了包含液压活塞式惯容器非线性因素的车辆惯容器 弹簧 阻尼器（inerter-spring-damper，简称ISD）悬架动力学模型并进行了仿真分析。结果表明，当考虑液压活塞式惯容器非线性因素时，车辆ISD悬架系统的车身加速度均方根值增加5%，而轮胎动载荷与悬架动行程均方根值均有所减小,降低了车辆的行驶平顺性。     

蓝宝石晶体掏棒机内冷式刀柄辅具结构研究

因蓝宝石晶体硬度为莫氏9级,仅次于最硬白金刚石,蓝宝石晶体掏棒加工中会产生很高的切削热量,筒刀和晶体必须进行筒刀内部和外部同时强力冷却,才能保证掏棒加工的稳定性和晶棒质量。所以蓝宝石晶体掏棒加工中要解决的关键技术问题之一,是内冷式刀柄辅具结构的研究、设计、试制、改进和联机使用。